Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ibuprofen-associated lipoid nephrosis without interstitial nephritis.

S J Morgenstern1, F J Bruns, D S Fraley

  • 1Montefiore Hospital, Pittsburgh, PA 15213.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|July 1, 1989
PubMed
Summary

Ibuprofen can cause lipoid nephrosis, a kidney condition, without interstitial nephritis. This case highlights the importance of drug history in kidney disease diagnosis, as symptoms resolved after stopping ibuprofen.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Female sex and survival in patients hospitalized with acute heart failure and renal dysfunction.

International journal of cardiology·2025
Same author

Three-dimensional anatomy of the junction between the posterior ethmoidal region and the sphenoid sinus.

Rhinology·2025
Same author

Tricuspid valve Swan-Ganz catheter entrapment before cardiac surgery.

Anaesthesia reports·2020
Same author

[Summary of two studies on the validation of the Critical Care Pain Observation Tool (CPOT) for assessment of pain in intensive care patients incapable of communication].

Der Anaesthesist·2020
Same author

Intra-patient potassium variability after hypothermic cardiac arrest: a multicentre, prospective study.

Scandinavian journal of trauma, resuscitation and emergency medicine·2019
Same author

Complications and results of the arthrodesis after total ankle arthroplasty failure: a retrospective monocentric study of 12 cases.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2019

Area of Science:

  • Nephrology
  • Pharmacology
  • Pathology

Background:

  • Lipoid nephrosis, a form of nephrotic syndrome, is characterized by lipid deposits in the renal tubules.
  • While often associated with various conditions, drug-induced cases require careful identification.
  • Interstitial nephritis is a common finding in drug-induced kidney injury, making isolated lipoid nephrosis rare.

Observation:

  • A case report details a patient presenting with lipoid nephrosis.
  • Crucially, the patient's kidney biopsy showed no evidence of interstitial nephritis.
  • The patient's medical history revealed significant ibuprofen use.

Findings:

  • The presented case is unique as it describes ibuprofen-associated lipoid nephrosis exclusively, without concurrent interstitial nephritis.

Related Experiment Videos

  • Previous reports often lacked detailed biopsy findings or included coexisting interstitial disease.
  • The patient's renal function and nephrotic syndrome resolved upon discontinuation of ibuprofen therapy.

    • Implications:

    • This case underscores the importance of considering non-steroidal anti-inflammatory drugs (NSAIDs), specifically ibuprofen, as a potential cause of isolated lipoid nephrosis.
    • Accurate histopathological examination and thorough patient history are critical for diagnosing drug-induced kidney injury.
    • Further research may elucidate the specific mechanisms by which ibuprofen induces lipoid nephrosis without interstitial inflammation.