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Densely ionizing radiation affects DNA methylation of selective LINE-1 elements

Sara Prior1, Isabelle R Miousse1, Etienne Nzabarushimana2

  • 1Department of Environmental and Occupational Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Environmental Research
|July 16, 2016
PubMed
Summary

DNA methylation regulates Long Interspersed Nucleotide Element 1 (LINE-1) retrotransposons. Densely ionizing radiation (IR) alters LINE-1 methylation and expression, with histone modifications playing a key role in response to dense IR.

Keywords:
EpigeneticsHigh-LET radiationHistone methylationIonizing radiationTransposable elements

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