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Related Experiment Video

Updated: Mar 17, 2026

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Signet-ring Cell Lymphoma-a Case Report.

N Masir1, S K Cheong2, K Noordin3

  • 1a Department of Histopathology Faculty of Medicine , Universiti Kebangsaan Malaysia , Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur , Malaysia.

Hematology (Amsterdam, Netherlands)
|July 16, 2016
PubMed
Summary

Signet-ring cell lymphoma, a rare follicular lymphoma variant, can mimic adenocarcinoma. Accurate diagnosis requires careful morphologic analysis and lymphoid marker testing for effective treatment.

Keywords:
Aspiration biopsyImmunohistochemistryLymphomaSignet-ring cell

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Area of Science:

  • Hematology
  • Oncology
  • Cytopathology

Background:

  • Signet-ring cell lymphoma is a rare variant of follicular lymphoma.
  • This lymphoma subtype can be mistaken for metastatic adenocarcinoma due to similar cell morphology.
  • Accurate initial diagnosis is crucial for appropriate patient management.

Purpose of the Study:

  • To report a case of signet-ring cell lymphoma diagnosed via fine needle aspiration cytology.
  • To highlight the diagnostic challenges posed by this rare lymphoma variant.
  • To emphasize the importance of specific diagnostic techniques.

Main Methods:

  • Fine needle aspiration (FNA) cytology was used for initial diagnosis.
  • Morphologic analysis of cytological samples was performed.
  • Immunohistochemical staining with lymphoid markers was utilized.
  • Electron microscopy was employed for detailed feature analysis.

Main Results:

  • The case presented with features mimicking metastatic adenocarcinoma.
  • Positive reactivity with lymphoid markers confirmed the diagnosis of lymphoma.
  • Cytohistologic, immunohistochemical, and electron microscopic findings are detailed.

Conclusions:

  • Signet-ring cell lymphoma is a rare entity requiring careful diagnostic consideration.
  • Fine needle aspiration cytology can be an effective initial diagnostic tool.
  • Integration of morphology and immunohistochemistry is essential for accurate diagnosis and differentiation from other signet-ring cell-appearing tumors.