Troponin and exercise.
1Department of Cardiology, Oslo University Hospital Ullevål and Institute of Clinical Sciences, University of Oslo, Oslo, Norway.
International Journal of Cardiology
|July 16, 2016
Summary
Exercise can elevate cardiac troponin levels, a key marker for myocardial infarction. This review explores factors influencing troponin release post-exercise, suggesting a likely physiological mechanism.
Area of Science:
- Cardiology
- Exercise Physiology
- Biomarkers
Background:
- Cardiac troponins are primary diagnostic markers for myocardial infarction.
- Elevated troponin levels are also observed following strenuous physical activity.
- Previous studies show varied results and debate regarding the mechanisms of exercise-induced troponin release.
Purpose of the Study:
- To review existing literature on exercise-induced increases in cardiac troponin.
- To identify factors influencing troponin levels after physical exertion.
- To elucidate the potential mechanisms behind troponin release during and after exercise.
Main Methods:
- A comprehensive literature search was conducted using PubMed.
- Additional relevant studies were identified through reference lists of initial findings.
- A total of 145 studies were included in the review.
Main Results:
- Troponin levels increased in 0-100% of subjects after prolonged or intermittent exercise.
- Factors influencing troponin variation include exercise intensity, age, training status, sample timing, and assay methods.
- The release pattern suggests a shift from the cardiomyocyte cytosolic compartment, potentially due to increased membrane permeability.
Conclusions:
- Both intense and moderate exercise can lead to elevated cardiac troponin levels.
- These findings must be considered in the clinical diagnosis of myocardial infarction in active individuals.
- The most probable mechanism for post-exercise troponin elevation appears to be physiological.
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