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Updated: Mar 17, 2026

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
Published on: January 27, 2023
Serum Ferritin as Risk Factor for Veno-occlusive Disease of the Liver. Prospective Cohort Study
M Morado1, E Ojeda1, J Garcia-Bustos1
1a Servicio de Hematología y Hemoterapia , Madrid . Spain.
Abstract:
Veno-occlusive disease of the liver (VOD) is an important complication in hematological transplantation. The aim of this study is to analyze the risk factors for VOD and other forms of liver toxicity in a cohort of 180 peripheral stem cell transplants performed in our Center. We find that elevated pretransplant levels of serum ferritin are the most important risk marker for VOD. We believe that ferritin reflects damage induced by oxygen radicals resulting from iron-mediated catalysis. We also discuss different risk factors for VOD and other forms of liver toxicity, suggesting diferent pathogenic mechanisms.
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