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Related Concept Videos

Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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RNA Splicing01:32

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Updated: Mar 17, 2026

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
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Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

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Regrowing axons with alternative splicing.

Nicholas J Kramer1, Aaron D Gitler2

  • 1Department of Genetics and the Neurosciences Graduate Program, Stanford University School of Medicine, Stanford, United States.

Elife
|July 16, 2016
PubMed
Summary
This summary is machine-generated.

Axon regeneration, crucial for nerve repair, is controlled by a new mechanism. This process involves CELF proteins regulating alternative splicing to promote nerve regrowth.

Keywords:
C. elegansCUGBPDRGPNS regenerationUNC-75mouseneurite outgrowthneurosciencepost-transcriptional regulation

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Axon regeneration is essential for functional recovery after nervous system injury.
  • Understanding the molecular mechanisms governing axon regrowth is critical for developing therapeutic strategies.

Purpose of the Study:

  • To elucidate a novel mechanism regulating axon regeneration.
  • To investigate the role of CELF proteins in controlling gene expression during axonal repair.

Main Methods:

  • Analysis of gene expression patterns during axon regeneration.
  • Investigating the function of CELF proteins using molecular biology techniques.
  • Studying the impact of alternative splicing on neuronal repair.

Main Results:

  • A previously unknown mechanism controlling axon regeneration was identified.
  • CELF proteins were found to regulate alternative splicing in neurons.
  • This regulation by CELF proteins is critical for successful axon regrowth.

Conclusions:

  • The findings reveal a new molecular pathway essential for axon regeneration.
  • Targeting CELF protein-mediated alternative splicing may offer therapeutic potential for nerve injury.