Related Experiment Video
Updated: Mar 17, 2026
07:51
Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
18.1K
Pregnancy and autoimmune connective tissue diseases
Wendy Marder1, Emily A Littlejohn2, Emily C Somers3
1Departments of Internal Medicine and OB/GYN, University of Michigan Medical School, NCRC B14-G236, 2800 Plymouth Rd, Ann Arbor, MI 48109-2800, USA.
Best Practice & Research. Clinical Rheumatology
|July 17, 2016
Summary
Planning pregnancy during inactive autoimmune connective tissue disease (ACTD) is crucial. Active ACTD increases risks, but optimized management ensures better maternal and fetal health outcomes.
Area of Science:
- Rheumatology
- Obstetrics
- Immunology
Background:
- Autoimmune connective tissue diseases (ACTD) primarily affect women of reproductive age.
- Pregnancy in women with ACTD presents unique challenges in planning and management.
- ACTD can impact both maternal health and pregnancy outcomes.
Purpose of the Study:
- To provide an overview of pregnancy in the context of ACTD.
- To discuss pregnancy as a risk factor for autoimmune disease onset.
- To outline management strategies for ACTD before, during, and after pregnancy.
Main Methods:
- Literature review of current research on ACTD and pregnancy.
- Synthesis of information on disease course, management, and medication.
- Analysis of pregnancy outcomes in relation to maternal disease activity.
Main Results:
- Active maternal ACTD during pregnancy is linked to adverse pregnancy outcomes.
- Conception during periods of inactive disease is associated with improved outcomes.
- Maintaining pregnancy-compatible treatment regimens is vital.
Conclusions:
- Optimizing maternal and fetal health requires careful planning and management of ACTD.
- Pre-conception counseling and disease control are essential for successful pregnancies in this population.
- Multidisciplinary care is recommended for pregnant women with ACTD.
Related Concept Videos
01:29Autoimmune Disorders
2.1K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
2.1K
01:22Connective Tissue Cell Types
4.4K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
4.4K
01:11Introduction to Connective Tissues
19.9K
Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
19.9K
01:24T Cell Types and Functions
3.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.1K
01:23Skin Diseases and Disorders
6.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.1K
01:15Transcytosis of IgG
4.4K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
4.4K