Antiphospholipid syndrome
M Khamashta1, M Taraborelli2, S Sciascia3
1Lupus Research Unit, The Rayne Institute, Division of Women's Health, Kings College London, St. Thomas Hospital, London, United Kingdom; Department of Rheumatology, Dubai Hospital, Dubai, United Arab Emirates.
Best Practice & Research. Clinical Rheumatology
|July 17, 2016
Summary
Antiphospholipid syndrome (APS) is an autoimmune disorder causing thrombosis and pregnancy issues. Current treatments focus on antithrombotic therapy, with new drugs being explored for better outcomes.
Area of Science:
- Immunology
- Hematology
- Obstetrics
Background:
- Antiphospholipid syndrome (APS) is an autoimmune condition linked to thrombosis and pregnancy complications.
- Thrombosis in APS stems from activated endothelial cells, monocytes, and platelets.
- Long-term antithrombotic therapy is standard for APS patients with thrombosis history due to high recurrence rates.
Purpose of the Study:
- To review the current understanding and management of antiphospholipid syndrome (APS).
- To discuss the pathogenesis and treatment of obstetrical APS.
- To identify areas needing further research, particularly for refractory cases.
Main Methods:
- Literature review of antiphospholipid syndrome (APS) management.
- Analysis of current treatment strategies for thrombosis and pregnancy morbidity in APS.
- Discussion of emerging therapeutic agents.
Main Results:
- Antiphospholipid syndrome (APS) management relies on antithrombotic therapy for thrombosis prevention.
- Current treatments enable live birth in 80% of obstetrical APS cases.
- Evidence supporting standard APS care is limited, necessitating clarification for complex cases.
Conclusions:
- Antiphospholipid syndrome (APS) requires ongoing research for optimal management strategies.
- Further investigation is needed for refractory and incomplete APS cases.
- Promising new therapeutic molecules are under development for APS treatment.
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