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Related Experiment Video

Updated: Mar 17, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Giant cell arteritis.

Jem Ninan¹, Susan Lester², Catherine Hill³

¹Rheumatology Unit, Modbury Hospital, Modbury, South Australia, Australia.

Best Practice & Research. Clinical Rheumatology

|July 17, 2016

Summary

This summary is machine-generated.

Giant cell arteritis (GCA) diagnosis is challenging in elderly patients. Advanced imaging and improved biopsy techniques, alongside understanding cytokine pathways, aid early detection and treatment for better outcomes.

Keywords:

Diagnosis Giant cell arteritis Imaging Management

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Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

Development and Identification of a Novel Subpopulation of Human Neutrophil-derived Giant Phagocytes In Vitro

Published on: January 25, 2017

Area of Science:

Rheumatology
Immunology
Vascular Medicine

Background:

Giant cell arteritis (GCA) is the most prevalent vasculitis affecting the elderly population.
Diagnostic challenges arise from limitations in American Rheumatology Association (ARA) classification criteria and a notable percentage of biopsy-negative GCA cases.
Understanding the pathogenesis of GCA is crucial for effective management.

Purpose of the Study:

To review advanced diagnostic modalities for GCA, including imaging and histopathology.
To explore the role of cytokine pathways in GCA pathogenesis and their therapeutic implications.
To discuss current and emerging treatment strategies for GCA.

Main Methods:

Review of advanced imaging techniques, such as positron emission tomography (PET) scanning.
Discussion of enhanced histopathology techniques for temporal artery biopsy.
Analysis of recent research on cytokine pathways (IL-6-IL-17, IL-12-IFN-γ) in GCA.

Main Results:

Advanced imaging and improved biopsy sensitivity can aid in diagnosing biopsy-negative GCA.
Cytokine pathways, particularly IL-6 and IL-17, are implicated in GCA pathogenesis.
Glucocorticoids remain the mainstay of treatment, but novel pharmacotherapies aim to reduce steroid burden and prevent relapse.

Conclusions:

Early diagnosis and prompt initiation of evidence-based treatment pathways improve patient outcomes in GCA.
Targeting specific cytokine pathways holds promise for future GCA therapies.
Multimodal diagnostic approaches and therapeutic advancements are essential for managing GCA effectively.