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Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow
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Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances

Clara Amalie Gade Timmermann1, Esben Budtz-Jørgensen2, Maria Skaalum Petersen3

  • 1Department of Environmental Medicine, University of Southern Denmark, J.B. Winsløws Vej 17A, 5000 Odense C, Denmark.

Reproductive Toxicology (Elmsford, N.Y.)
|July 17, 2016
PubMed

The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed. In two Faroese birth cohorts (N=1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding.

Keywords:
Breast milkBreastfeedingEndocrine disruptionLactationMaternal healthPerfluoroalkyl substances

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