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Postural tremor and chronic inflammatory demyelinating polyneuropathy.
Yiming Cao1, Parvathi Menon1,2, Florence Ching-Fen Chang1,2
1Western Clinical School, University of Sydney, Sydney, Australia.
Muscle & Nerve
|July 17, 2016
Summary
Tremor is a frequent and disabling symptom in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). This study found significantly higher tremor frequency and severity in CIDP patients compared to controls.
Area of Science:
- Neurology
- Clinical Neuroscience
Background:
- Chronic inflammatory demyelinating polyneuropathy (CIDP) often involves sensory and motor deficits.
- Tremor is a recognized, yet poorly understood, debilitating symptom in CIDP patients.
Purpose of the Study:
- To investigate the prevalence and characteristics of tremor in CIDP patients.
- To compare tremor severity and disability in CIDP patients versus neuromuscular controls.
Main Methods:
- Prospective collection of clinical tremor severity and disability scores.
- Comparison between 25 CIDP patients and 22 neuromuscular controls.
- Utilized accelerometry to characterize tremor frequency.
Main Results:
- 80% of CIDP patients experienced postural and kinetic tremor, versus 35% in controls (P < 0.005).
- CIDP patients exhibited significantly greater tremor severity and related disability.
- Accelerometry confirmed 5.5 Hz postural and 5 Hz kinetic tremor in CIDP patients.
Conclusions:
- Tremor is a prevalent and disabling clinical feature of CIDP.
- Sensory and motor impairments in CIDP may contribute to tremor development.
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