Related Experiment Videos
Skin and serum reactivity to some storage mites in children sensitive to Dermatophagoides pteronyssinus
A L Boner1, C Richelli, G Vallone
1Clinica Pediatrica Universitá di Verona, Italy.
Abstract:
The incidence of skin test and RAST positivity for Dermatophagoides farinae and storage mites (Glycyphagus privatus, Lepidoglyphus destructor, Tyrophagus putrescentiae, Acarus siro, and Gohieria fusca) have been evaluated in children with bronchial asthma and positive prick test to Dermatophagoides pteronyssinus. The storage mite with highest incidence of skin and RAST positivity was Gohieria fusca, which caused a positive response in more than 50% of the children evaluated. This antigen appears to possess allergenic determinants not present in Dermatophagoides pteronyssinus. The sensitivity to this antigen might be considered in house dust mite-allergic children who do not improve after specific immunotherapy with Dermatophagoides pteronyssinus extracts.
Insights
Gohieria fusca mites are a significant allergen in children with asthma, showing high rates of skin and RAST positivity. This finding suggests Gohieria fusca may be a crucial allergen to consider in treatment-resistant house dust mite allergies.
Area of Science:
- Allergy and Immunology
- Pediatric Pulmonology
- Environmental Allergens
Background:
- Bronchial asthma in children is often linked to allergies.
- House dust mites are common triggers, particularly Dermatophagoides pteronyssinus.
- The role of storage mites in pediatric asthma requires further investigation.
Purpose of the Study:
- To evaluate the incidence of skin and RAST positivity for Dermatophagoides farinae and various storage mites in children with bronchial asthma.
- To identify specific mite allergens that may be relevant in children with a known allergy to Dermatophagoides pteronyssinus.
Main Methods:
- Skin prick tests and RAST (Radioallergosorbent Test) were performed.
- Patients included children with bronchial asthma and a positive prick test to Dermatophagoides pteronyssinus.
- Allergens tested included Dermatophagoides farinae and several storage mites (Glycyphagus privatus, Lepidoglyphus destructor, Tyrophagus putrescentiae, Acarus siro, Gohieria fusca).
Main Results:
- Gohieria fusca demonstrated the highest incidence of skin and RAST positivity among the evaluated mites, exceeding 50% in the study group.
- The allergenic determinants of Gohieria fusca appear distinct from those found in Dermatophagoides pteronyssinus.
- A significant portion of children with asthma and Dermatophagoides pteronyssinus allergy also reacted to Gohieria fusca.
Conclusions:
- Gohieria fusca is a prevalent allergen in children with bronchial asthma and Dermatophagoides pteronyssinus sensitivity.
- This storage mite possesses unique allergenic properties not shared with Dermatophagoides species.
- Consideration of Gohieria fusca sensitivity is recommended for house dust mite-allergic children unresponsive to standard immunotherapy.