Related Experiment Video

Updated: Mar 17, 2026

Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure
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Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure

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128

Left ventricular non-compaction cardiomyopathy and left ventricular assist device: a word of caution

A Kornberger1, U A Stock2, P Risteski2

  • 1Department of Thoracic and Cardiovascular Surgery, University Hospital Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany. Angela.Kornberger@kgu.de.

Journal of Cardiothoracic Surgery
|July 17, 2016
PubMed

Insights

Left ventricular assist device (LVAD) support in patients with left ventricular non-compaction (LVNC) can cause inflow cannula obstruction. Close monitoring of LVAD function and cardiac configuration is crucial for these patients.

Area of Science:

  • Cardiology
  • Medical Devices
  • Cardiac Surgery

Background:

  • Left ventricular assist device (LVAD) implantation is a strategy for end-stage heart failure.
  • Left ventricular non-compaction (LVNC) presents unique challenges for LVAD therapy.
  • LVADs are used as a bridge to transplantation in eligible patients.

Observation:

  • A patient with LVNC experienced inflow cannula obstruction nine months post-LVAD implantation.
  • Urgent heart transplantation was required due to the obstruction.
  • Echocardiography and explanted heart examination revealed LVAD-induced changes in left ventricular configuration.

Findings:

  • LVAD support can alter the configuration of the non-compacted myocardium.
  • These configurational changes can lead to inflow cannula obstruction and reduced LVAD flow.
  • The interaction between LVNC and LVAD support poses a risk for device malfunction.

Implications:

  • Continuous surveillance of LVAD performance and ventricular morphology is essential in LVNC patients.
  • Prompt identification of LVAD-related complications is critical.
  • Patients with LVNC and LVAD support may warrant expedited consideration for heart transplantation.
Abstract

Keywords:
Heart transplantationInflow obstructionLeft ventricular assist deviceLeft ventricular non-compaction

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