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Updated: Mar 17, 2026
Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments
Published on: May 26, 2019
Facility for gamma irradiations of cultured cells at low dose rates: design, physical characteristics and functioning
Giuseppe Esposito1, Pasquale Anello2, Ilaria Pecchia2
1Health and Technology Department, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy; INFN Roma1, Gruppo Collegato Sanità, Viale Regina Elena 299, 00161 Roma, Italy.
Abstract:
We describe a low dose/dose rate gamma irradiation facility (called LIBIS) for in vitro biological systems, for the exposure, inside a CO2 cell culture incubator, of cells at a dose rate ranging from few μGy/h to some tens of mGy/h. Three different (137)Cs sources are used, depending on the desired dose rate. The sample is irradiated with a gamma ray beam with a dose rate uniformity of at least 92% and a percentage of primary 662keV photons greater than 80%. LIBIS complies with high safety standards.
