Related Experiment Video
Updated: Mar 17, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Genetic, hormonal and metabolic aspects of PCOS: an update
V De Leo1, M C Musacchio2, V Cappelli2
1Department Molecular Medicine and Development, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100, Siena, Italy. vincenzo.deleo@unisi.it.
Abstract:
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 5-10 % of women of reproductive age. It generally manifests with oligo/anovulatory cycles, hirsutism and polycystic ovaries, together with a considerable prevalence of insulin resistance. Although the aetiology of the syndrome is not completely understood yet, PCOS is considered a multifactorial disorder with various genetic, endocrine and environmental abnormalities. Moreover, PCOS patients have a higher risk of metabolic and cardiovascular diseases and their related morbidity, if compared to the general population.
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