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Nicorandil-induced penile ulceration: a case report
Darren Yap1, Omar Aboumarzouk2, Christopher Bates2
1Department of Urology, Royal Gwent Hospital, Cardiff Road, Newport, NP20 2UB, UK. darrenyap.jx@gmail.com.
Journal of Medical Case Reports
|July 18, 2016
Summary
Penile ulceration can rarely be caused by nicorandil, a medication for angina. Stopping nicorandil treatment led to the spontaneous resolution of penile ulcers in an elderly patient.
Area of Science:
- Urology
- Dermatology
- Pharmacology
Background:
- Penile ulceration in elderly patients often suggests malignancy or infection.
- Rarer causes of penile ulceration must be considered in differential diagnoses.
- Nicorandil, a nicotinamide ester used for angina, is an uncommon cause of penile ulceration.
Observation:
- An 86-year-old man presented with a year-long history of penile discharge and a palpable mass.
- The patient had been on nicorandil for five years to manage angina.
- Biopsy revealed inflammation, excluding malignancy.
Findings:
- Penile ulceration resolved spontaneously after the patient discontinued nicorandil.
- This case highlights nicorandil as a potential cause of penile ulceration.
Implications:
- Nicorandil-induced penile ulceration is a rare but significant clinical consideration.
- Prompt diagnosis and discontinuation of nicorandil are crucial for resolution.
- Referral for biopsy is recommended when the etiology of penile ulceration is uncertain.
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