Related Experiment Video
Updated: Mar 17, 2026
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Endometrial spatio-temporal image correlation (STIC) and prediction of outcome following assisted reproductive
Lukasz T Polanski1, Miriam N Baumgarten1, Jan Brosens2
1School of Medicine, University of Nottingham, Nottingham, United Kingdom.
Objective:
The aim of this study was to correlate manual and spherical endometrial spatio-temporal image correlation (STIC) vascularity indices with assisted reproductive treatment (ART) outcomes.
Study Design:
STIC ultrasound assessments of the endometrium were carried out at three time-points in 127 women in a prospective observational study.
Results:
Biochemical pregnancy rate was 69% (88/127), with a biochemical and clinical pregnancy loss of 17%. Endometrial STIC vascularity indices in the assessed time-points did not differ between subjects who achieved a clinical pregnancy and those who did not (P>0.05). For first trimester miscarriage, minimal manual vascularization index (VI) at oocyte collection (cut-off value ≥0.7; sensitivity 80.0% and specificity 68.1%) demonstrated the highest area under the curve (AUC) of 0.8.
Conclusion:
In summary, STIC modality is not a useful tool to predict ART outcome, however manual STIC analysis of endometrial vascularity seems to be more accurate in predicting first trimester pregnancy loss.
