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Updated: Mar 17, 2026
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
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[Prostate cancer microenvironment: Its structure, functions and therapeutic applications].
Summary
The prostate tumor microenvironment, comprising immune cells and vasculature, significantly influences cancer progression. Emerging therapies targeting this ecosystem, like antiangiogenic treatments and immunotherapy, show promise but require further investigation.
Area of Science:
- Oncology
- Cancer Biology
- Immunology
Background:
- The tumor microenvironment (TME) is increasingly recognized as a critical factor in prostate cancer development and progression.
- Understanding the TME's structure and function is essential for developing effective cancer therapies.
Purpose of the Study:
- To describe the structure and functions of the prostate cancer microenvironment.
- To outline principal treatments targeting the prostate cancer microenvironment.
Main Methods:
- A systematic literature search was conducted on PubMed and ScienceDirect.
- Keywords included "tumour microenvironment," "neoplasm therapy," "microenvironnement tumoral," and "traitements."
- 50 articles were included from an initial pool of 593.
Main Results:
- The TME consists of host elements, including immune cells, support tissues, and neovascularization (vascular and lymphatic), that promote tumor growth.
- The TME plays a major role in prostate cancer, leading to the development of targeted treatments such as antiangiogenic therapy and immunotherapy.
Conclusions:
- The TME, tumor, and host are in constant mutual influence, creating a dynamic biological situation.
- Enhanced understanding of the prostate cancer TME facilitates a shift from tumor-centric to ecosystem-focused approaches.
- New TME-targeted treatments are emerging, but their optimal role in the therapeutic arsenal needs further definition.
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