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Peripheral Artery Disease III: Interprofessional Care

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Related Experiment Video

Updated: Mar 17, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Determining End Points for Critical Limb Ischemia Interventions.

Kyle J Cooper¹, Constantino Peña¹, James Benenati¹

¹Miami Cardiac & Vascular Institute, Miami, FL.

Techniques in Vascular and Interventional Radiology

|July 18, 2016

Summary

This summary is machine-generated.

Assessing therapeutic end points after critical limb ischemia revascularization is crucial for healing. Utilizing intraprocedural and postprocedural tools helps optimize patient outcomes and guides clinical decisions.

Keywords:

Peripheral vascular disease critical limb ischemia postprocedural testing therapeutic end points

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Methods for Acute and Subacute Murine Hindlimb Ischemia

Methods for Acute and Subacute Murine Hindlimb Ischemia

Published on: June 21, 2016

Area of Science:

Vascular Surgery
Interventional Cardiology
Wound Healing

Background:

Critical limb ischemia (CLI) prevalence and morbidity are increasing.
Endovascular therapy for CLI has advanced, but healing can take months.
Therapeutic end points for revascularization in CLI patients are not always clear.

Purpose of the Study:

To review current and emerging tools for assessing revascularization success in CLI.
To define key intraprocedural and postprocedural end points for optimizing patient outcomes.

Main Methods:

Review of intraprocedural assessments: in-line flow, angiosome perfusion, wound blush, pulse restoration, and ulcer bleeding.
Evaluation of postprocedural noninvasive tests: ankle-brachial index, toe-brachial index, segmental pressures, pulse volume recordings, transcutaneous oxygen tension, skin perfusion pressures (SPPs), and toe pressures.
Discussion of newer technologies: 2D perfusion angiography, fluorescence angiography, and tissue oxygen saturation mapping.

Main Results:

Intraprocedural assessment focuses on immediate flow restoration to the affected area.
Postprocedural noninvasive tests provide objective measures of improved circulation.
Advanced imaging techniques offer real-time evaluation of perfusion and tissue oxygenation.

Conclusions:

A combination of clinical assessment, noninvasive testing, and advanced imaging is essential for evaluating revascularization success in CLI.
Clear therapeutic end points guide physicians in optimizing treatment and improving wound healing.
Close follow-up and wound care are critical components in managing CLI patients post-revascularization.