Related Experiment Video
Updated: Mar 17, 2026
Toxicological Assays for Testing Effects of an Epigenetic Drug on Development, Fecundity and Survivorship of Malaria Mosquitoes
Published on: January 16, 2015
A comparative study of azithromycin and sulphadoxine-pyrimethamine as prophylaxis against malaria in pregnancy
Rukiyat Adeola Abdus-Salam1, Folasade Adenike Bello2, Fatai A Fehintola3
1Department of Obstetrics and Gynaecology, Adeoyo Maternity Teaching Hospital, Ibadan, Oyo State, Nigeria.
Context:
The benefit of malaria prophylaxis in pregnancy is threatened by emergence of Plasmodium falciparum resistance to antimalarial agents for chemoprophylaxis and treatment.
Aim:
This study aimed to compare the effectiveness of azithromycin (AZ) with sulphadoxine-pyrimethamine (SP) for malaria prevention.
Settings And Design:
A prospective comparative study of antenatal clinic attendees at the University College Hospital, Ibadan, Nigeria. Participants were randomised to receive SP or AZ.
Subjects And Methods:
The subjects were antenatal attendees and Samples for malaria parasitaemia were collected and repeated at follow-up visits; maternal peripheral blood film, placental and cord blood samples were collected at delivery.
Statistical Analysis Used:
Chi-square test and t-test in a per-protocol analysis.
Results:
Of 200 participants (100 in each group), 166 (83.0%) completed the study: 86 (86.0%) of SP and 80 (80.0%) of AZ groups, respectively (P = 0.26). Four (4.7%) participants who had SP compared to five (6.2%) in AZ group developed malaria at mean gestational ages of 30.3 ± 1.56 and 33.0 ± 8.6, respectively (P = 0.56). Positive peripheral, placental and cord blood parasitaemia were found in ≤2% of the participants. Drug tolerability and foetal outcomes were comparable for both groups.
Conclusion:
AZ was comparable to SP for prevention of malaria in pregnancy and may be used in patients who do not tolerate SP.
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