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Cell Therapy for Bronchopulmonary Dysplasia: Promises and Perils

Marius Alexander Möbius1, Bernard Thébaud2

  • 1Department of Neonatology and Pediatric Critical Care Medicine, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; DFG Research Center and Cluster of Excellence for Regenerative Therapies (CRTD), Technische Universität Dresden, Dresden, Germany; Sinclair Centre for Regenerative Medicine, Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.

Paediatric Respiratory Reviews
|July 19, 2016
PubMed

Insights

Stem and progenitor cell therapies offer hope for protecting and regenerating immature lungs damaged by bronchopulmonary dysplasia (BPD), a common complication of premature birth. While still experimental, early clinical trials show promise for treating neonatal lung injury.

Area of Science:

  • Neonatal medicine and perinatal care
  • Regenerative medicine and stem cell biology
  • Pulmonology and respiratory disease

Background:

  • The immature lung is highly vulnerable after premature birth, with bronchopulmonary dysplasia (BPD) being the most frequent complication.
  • BPD leads to impaired lung development and potential lifelong health issues, lacking effective preventative or therapeutic strategies.
  • Current treatments for BPD are limited, highlighting the urgent need for novel approaches in neonatal intensive care.

Purpose of the Study:

  • To review the role of stem and progenitor cells in the development and therapeutic strategies for bronchopulmonary dysplasia.
  • To discuss the potential clinical applications of cell-based therapies for preventing neonatal lung injury.
  • To examine challenges in manufacturing clinical-grade cell products for premature infants.

Main Methods:

  • Review of current scientific literature on stem/progenitor cell biology and their application in BPD models.
  • Analysis of early-phase clinical trial data regarding cell therapies for neonatal lung conditions.
  • Examination of regulatory and manufacturing considerations for clinical translation of cell products.

Main Results:

  • Stem and progenitor cells show potential for protecting and regenerating immature lungs in preclinical BPD models.
  • Early clinical trials are underway, indicating progress towards therapeutic use of these cells in premature infants.
  • Understanding the precise mechanisms of action for stem cell therapy in BPD requires further investigation.

Conclusions:

  • Stem/progenitor cell therapy represents a promising avenue for treating bronchopulmonary dysplasia and neonatal lung injury.
  • Further research is needed to elucidate mechanisms and optimize cell-based treatments for clinical application.
  • Addressing manufacturing and regulatory hurdles is crucial for the successful implementation of these therapies in neonatal care.

Keywords:
bronchopulmonary dysplasiacell therapy.injurylungmesenchymal stromal cellsstem cells

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