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Triterpenoids from the fruit of Schisandra glaucescens
Heng-Yi Yu1, Juan Li2, Ye Liu3
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China; Department of Pharmacy, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
Abstract:
Five new triterpenoids, named schiglausins P-T (1-5), together with twelve known analogues (6-17), were isolated from the fruit of Schisandra glaucescens Diels. Their structures were determined by various spectroscopic methods, including HRESIMS, 1D and 2D NMR spectra and CD experiment. Additionally, all these compounds were tested for their cytotoxicities against B16 mouse melanoma cell line. Compounds 8, 11, 14, and 15 exhibited moderate anti-proliferative effects against B16 cells with IC50 values ranging from 3.64 to 27.00μM.
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