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HLA in autonomic failure.

L E Nee1, R T Brown, R J Polinsky

  • 1Clinical Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Bethesda, Md. 20892.

Archives of Neurology
|July 1, 1989
PubMed
Summary
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This study found no significant link between HLA antigens and autonomic nervous system disorders like pure autonomic failure or multiple system atrophy. These findings challenge previous research suggesting a genetic contribution.

Area of Science:

  • Immunogenetics
  • Neurology
  • Autonomic Nervous System Disorders

Background:

  • Previous studies suggested a potential association between Human Leukocyte Antigen (HLA) antigens and autonomic nervous system disorders.
  • Pure autonomic failure (PAF) and multiple system atrophy with autonomic failure (MSA-AF) are debilitating neurological conditions affecting autonomic function.

Purpose of the Study:

  • To investigate the association between specific HLA antigens and the development of pure autonomic failure (PAF) and multiple system atrophy with autonomic failure (MSA-AF).
  • To determine if HLA-A32 is a risk factor for these autonomic disorders.

Main Methods:

  • Case-control study comparing HLA antigen frequencies in patients with PAF and MSA-AF against a control group (details not provided in the abstract).
  • Statistical analysis to assess the significance of HLA antigen associations.

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Main Results:

  • No statistically significant association was found between HLA antigens and either pure autonomic failure or multiple system atrophy with autonomic failure.
  • The HLA-A32 antigen was not found to occur with increased frequency in patients with these autonomic disorders.

Conclusions:

  • The study's findings do not support a contribution of HLA antigens in the pathogenesis of pure autonomic failure and multiple system atrophy with autonomic failure.
  • These results contradict previous research suggesting a genetic link via HLA in these autonomic nervous system disorders.