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Individuals hospitalized with acute mania have increased exposure to antimicrobial medications

Robert Yolken1, Maria Adamos2, Emily Katsafanas2

  • 1Stanley Neurovirology Laboratory, Johns Hopkins School of Medicine, Baltimore, MD,, USA.

Bipolar Disorders
|July 19, 2016
PubMed
Abstract

Insights

Individuals with acute mania show significantly higher rates of bacterial infections, indicated by antibiotic prescriptions. Addressing these infections could be key in managing mania symptoms and improving patient outcomes.

Area of Science:

  • Psychiatry
  • Infectious Diseases
  • Immunology

Background:

  • Acute mania is associated with immune activation, but the source remains unclear.
  • Bacterial infections are a potential, yet under-investigated, contributor to immune activation in acute mania.

Purpose of the Study:

  • To investigate the prevalence of bacterial infections in individuals hospitalized with acute mania.
  • To determine if bacterial infections, evidenced by antimicrobial prescriptions, are a source of immune activation in acute mania.

Main Methods:

  • Retrospective assessment of systemic antimicrobial prescriptions in 234 individuals hospitalized for acute mania.
  • Comparison of antibiotic prescription rates between acute mania patients, other psychiatric disorder patients (n=368), and controls (n=555).
  • Logistic regression analysis was used to compare antibiotic prescription rates, controlling for demographic variables.

Main Results:

  • Individuals with acute mania had a significantly higher rate of recent antibiotic prescription (7.7%) compared to controls (1.3%).
  • Antibiotic prescription was linked to inpatient status and mania symptom severity, not other clinical or demographic factors.
  • Common infection sites included the urinary tract in women and respiratory/mucosal sites in men.

Conclusions:

  • Hospitalized individuals with acute mania exhibit a substantially elevated incidence of bacterial infections.
  • Effective prevention and treatment of bacterial infections may represent crucial therapeutic strategies for managing acute mania.
Keywords:
antibioticinfectioninflammationmania

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