[A simple, convenient method for the synthesis of acyclic analogs of guanosine]

A simple convenient method for the synthesis of guanosine acyclic analogues with the nucleic base attached to the primary carbon atom is proposed. The method involves treatment of trimethylsilyl derivative of guanine with agents of general formula ROCH2Cl in the absence of Lewis acids. 9-Substituted derivatives of guanine were prepared by this method with 50-65% yields.