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Sodium butyrate modulates a methamphetamine-induced conditioned place preference.

Jie Zhu1,2, Na Zhao1,3, Yanjiong Chen4

  • 1College of Forensic Medicine, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.

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Histone acetylation influences methamphetamine addiction. Sodium butyrate (NaB) facilitated methamphetamine-induced conditioned place preference (CPP) acquisition and extinction, and repeated NaB treatment blocked CPP reinstatement.

Keywords:
conditioned place preferencehistone acetylationmemorymethamphetaminesodium butyrate

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Histone acetylation is known to modulate gene expression, impacting neuroplasticity and addictive behaviors.
  • The specific role of histone acetylation in different stages of methamphetamine (METH)-induced conditioned place preference (CPP) is not well understood.

Purpose of the Study:

  • To investigate the effects of the histone deacetylases (HDACs) inhibitor, sodium butyrate (NaB), on the acquisition, extinction, and reinstatement of METH-induced CPP in mice.

Main Methods:

  • Mice were conditioned with methamphetamine (1 mg/kg) to induce CPP.
  • Sodium butyrate (400 mg/kg) was administered during conditioning, extinction, or reinstatement phases.
  • CPP acquisition, extinction, and reinstatement were assessed following NaB treatment.

Main Results:

  • METH successfully induced CPP, which was later extinguished and could be reinstated.
  • NaB administration during conditioning facilitated METH-induced CPP acquisition.
  • NaB administration during extinction facilitated the extinction of METH-induced CPP and blocked its reinstatement with repeated administration.

Conclusions:

  • Histone acetylation, modulated by NaB, plays a distinct role in regulating different phases of METH-induced CPP.
  • NaB treatment during the extinction phase is effective in eliminating established CPP and preventing its relapse.