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D-dimers (DD) in CVST.

Hui Fang Wang1,2, Chuan Qiang Pu1, Xi Yin1

  • 1a Department of Neurology , Chinese People's Liberation Army General Hospital , Beijing , P.R. China.

The International Journal of Neuroscience
|July 19, 2016
PubMed
Summary
This summary is machine-generated.

D-dimer levels are elevated in patients with acute/subacute cerebral venous sinus thrombosis (CVST). Elevated D-dimer is associated with shorter symptom duration, more risk factors, and increased venous sinus involvement in CVST patients.

Keywords:
D-dimerblood glucosecerebral venous sinus thrombosisnumber of venous sinuses involvementsymptom duration

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Area of Science:

  • Neurology
  • Hematology
  • Diagnostic Medicine

Background:

  • Cerebral venous sinus thrombosis (CVST) is a rare but serious condition.
  • The diagnostic utility of D-dimer (DD) levels in CVST requires further confirmation.

Purpose of the Study:

  • To investigate the elevation of D-dimer levels in patients diagnosed with cerebral venous sinus thrombosis.
  • To identify clinical and laboratory factors associated with elevated D-dimer in CVST.

Main Methods:

  • A cohort of 139 CVST patients were categorized into elevated D-dimer group (EDG) and normal D-dimer group (NDG).
  • Demographic, clinical, laboratory, and imaging data were compared between the two groups.
  • Inferential statistical methods, including chi-squared, Fisher exact, correlation, and multivariate logistic regression analyses, were employed.

Main Results:

  • Patients with elevated D-dimer showed significantly shorter symptom duration, more risk factors, and higher multiple venous sinus involvement compared to the normal D-dimer group.
  • D-dimer levels positively correlated with the number of venous sinuses involved.
  • Symptom duration, number of venous sinuses involved, and presence of risk factors were significant predictors differentiating the groups.

Conclusions:

  • D-dimer is elevated in patients experiencing acute or subacute cerebral venous sinus thrombosis.
  • Elevated D-dimer levels in CVST are associated with specific clinical characteristics and disease severity indicators.