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A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Virologic and immunologic aspects of HIV-hepatitis C virus coinfection
Kara W Chew1, Debika Bhattacharya
1David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Abstract:
HIV/hepatitis C virus (HCV) coinfection is estimated to affect 2 million individuals globally. The acceleration of HCV-associated complications, particularly hepatic fibrosis, because of HIV coinfection has been well established, whereas the impact of HCV on HIV progression remains unclear. In this review, we summarize the current evidence on the impact of coinfection on the transmission and clinical progression of each infection. We focus on the virological and immunological alterations that contribute to HIV and HCV pathogenesis in coinfection and also review the disease-modifying effects of antiretroviral therapy as they pertain to HCV.
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