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Updated: Mar 17, 2026
In Vivo Mouse Model of Spinal Implant Infection
Published on: June 23, 2020
Surgical Site Infections Caused by Methicillin-resistant Staphylococcus epidermidis After Spinal Instrumentation
Takashi Takizawa1, Takahiro Tsutsumimoto, Mutsuki Yui
1Spine Center, Yodakubo Hospital, Nagawa, Nagano, Japan.
Study Design:
Retrospective case series.
Objective:
To determine relevant demographics, clinical presentations, and outcomes of surgical site infections (SSIs) after spinal instrumentation (SI) surgery caused by methicillin-resistant Staphylococcus epidermidis (MRSE).
Summary Of Background Data:
This is the first study looking specifically at MRSE-related SSIs after SI surgery.
Methods:
We performed a retrospective review of patients with MRSE-related SSIs from 665 consecutive cases of SI surgery performed between 2007 and 2014 at our institution.
Results:
During the study period, SSIs occurred in 21 patients. MRSE was isolated from cultures obtained from surgical wounds in nine of the 21 patients (43%). There were four males and five females with a mean age of 63.9 ± 15.1 years. Six patients presented with inflammatory signs, such as wound drainage, pyrexia, erythema, and elevated C-reactive protein. Three patients did not have signs of infection, but had early implant failure, and were diagnosed by positive cultures collected at the time of revision surgery. The mean time from index surgery to the diagnosis of infection was 23.6 days (range, 7-88 days). In one patient, the implant was removed before antibiotic treatment was administered because of implant failure. Eight patients were managed with antibiotics and implant retention. During the follow-up period, MRSE-related SSIs in seven of the eight patients were resolved with implant retention and antibiotics without the need for further surgical intervention. One patient did not complete the antibiotic course because of side effects, and implant removal was required to control the infection.
Conclusion:
Early detection, surgical debridement, and administration of appropriate antibiotics for a suitable duration enabled infection control without the need for implant removal in the treatment of MRSE-related SSI after SI surgery.
Level Of Evidence:
4.
