Efficacy of Monsel Solution After Cervical Biopsy: A Randomized Trial

Area of Science:

• Gynecology
• Surgical Hemostasis

Background:

• Cervical punch biopsy is a common gynecological procedure.
• Post-biopsy vaginal bleeding (VB) can occur, necessitating effective hemostatic agents.

Purpose of the Study:

• To evaluate the efficacy of Monsel solution in controlling vaginal bleeding after cervical punch biopsy.
• To assess the side effects, pain, and patient satisfaction associated with Monsel solution use.

Main Methods:

• A prospective, randomized trial comparing Monsel solution to a "wait and see" approach.
• Primary endpoint: vaginal bleeding measured by a 5-level pictogram score after 15 minutes.
• Secondary endpoints included bleeding at 3, 6, and 24 hours, subjective bleeding, pain, and satisfaction.

Main Results:

• Monsel solution significantly reduced vaginal bleeding at 15 minutes (P < 0.001) and at 3 and 6 hours (P < 0.001).
• No significant difference in bleeding was observed at 24 hours (P = 0.4).
• Subjective bleeding was lower with Monsel solution (P < 0.001), but pain and satisfaction were comparable between groups.

Conclusions:

• Monsel solution is effective in reducing immediate and short-term vaginal bleeding following cervical punch biopsy.
• The application of Monsel solution does not adversely affect patient-reported pain or overall satisfaction.