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Matrix metalloproteinase-1 rs1799750 polymorphism and glaucoma: A meta-analysis
Miao He1, Wei Wang1, Xiao Han1
1a Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology , Sun Yat-Sen University , Guangzhou , China.
Ophthalmic Genetics
|July 19, 2016
Summary
The matrix metalloproteinase-1 (MMP-1) rs1799750 polymorphism is linked to increased glaucoma susceptibility. This meta-analysis confirms a significant association between this genetic marker and various forms of glaucoma.
Area of Science:
- Genetics
- Ophthalmology
- Molecular Biology
Background:
- The -1607 1G/2G (rs1799750) polymorphism in the matrix metalloproteinase-1 (MMP-1) gene promoter has been investigated for its potential association with glaucoma.
- Previous studies have yielded controversial results regarding the link between this specific polymorphism and glaucoma susceptibility.
Purpose of the Study:
- To conduct a meta-analysis to systematically evaluate the association between the MMP-1 -1607 1G/2G (rs1799750) polymorphism and the risk of developing glaucoma.
- To resolve the conflicting findings from prior individual studies.
Main Methods:
- A comprehensive literature search was performed across major databases, including Pubmed, Embase, Web of Science, and the Chinese Biomedical database.
- Five case-control studies comprising 1261 glaucoma patients and 1089 controls were included in the meta-analysis.
- Data were pooled using fixed or random effect models, and results were expressed as odds ratios (ORs) with 95% confidence intervals (CIs).
Main Results:
- The meta-analysis revealed a significant association between the rs1799750 polymorphism and glaucoma risk across homozygote, recessive, and allelic models.
- Subgroup analyses indicated significant associations with primary angle closure glaucoma (homozygote and allelic models), primary open angle glaucoma (recessive model), and exfoliation glaucoma (recessive model).
- No evidence of publication bias was detected in the included studies.
Conclusions:
- The rs1799750 polymorphism in the MMP-1 gene promoter may influence an individual's susceptibility to glaucoma.
- Further research with larger sample sizes and diverse ethnic populations is recommended to solidify these findings due to the limited number of studies currently available.
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