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Updated: Mar 17, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
Impact of CDT Toxin on Human Diseases
Tiphanie Faïs1,2,3, Julien Delmas4,5,6, Arnaud Serres7
1Microbes, Inflammation, Intestin et Susceptibilité de l'Hôte (M2iSH), Clermont Université, Université d'Auvergne; INSERM U1071; INRA USC2018, Clermont-Ferrand 63000, France. tfais@chu-clermontferrand.fr.
Abstract:
Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the Enterobacteriaceae family and the Campylobacterales order, including the Campylobacter and Helicobacter species. In vitro and in vivo studies have clearly shown that this toxin has a strong effect on cellular physiology (inflammation, immune response modulation, tissue damage). Some works even suggest a potential involvement of CDT in cancers. In this review, we will discuss these different aspects.
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