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Strontium eluting nanofibers augment stem cell osteogenesis for bone tissue regeneration
Sai Rama Krishna Meka1, Shubham Jain1, Kaushik Chatterjee1
1Department of Materials Engineering, Indian Institute of Science, Bangalore 560012, India.
Colloids and Surfaces. B, Biointerfaces
|July 19, 2016
Summary
Strontium carbonate nanoparticles enhance poly(ε-caprolactone) scaffolds for bone regeneration. These nanocomposite scaffolds promote human mesenchymal stem cell proliferation and osteogenesis, offering a promising alternative to growth factors.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Strontium (Sr) is recognized for its therapeutic effects in osteoporosis by stimulating bone formation.
- Polymer nanocomposite scaffolds are being explored for bone tissue regeneration applications.
Purpose of the Study:
- To engineer poly(ε-caprolactone) (PCL) nanocomposite scaffolds incorporating strontium carbonate nanoparticles (nSrCO3) for enhanced bone tissue regeneration.
- To evaluate the effect of nSrCO3 incorporation on scaffold properties and osteogenic potential.
Main Methods:
- Electrospinning was used to fabricate PCL nanocomposite scaffolds with 10% and 20% nSrCO3 (PCL/SrC10, PCL/SrC20).
- Physicochemical properties (crystallinity, elastic modulus, ion release) were analyzed.
- In vitro studies assessed human mesenchymal stem cell proliferation, mineral deposition, and expression of osteogenic markers (BMP-2, Osterix, Runx2).
Main Results:
- PCL/SrC20 scaffolds exhibited controlled release of Sr(2+) ions (up to 65ppm in 4 days).
- Incorporation of nSrCO3 reduced PCL crystallinity and elastic modulus.
- PCL/SrC20 significantly enhanced human mesenchymal stem cell proliferation, mineral deposition (four-fold increase), and osteogenic marker expression compared to PCL alone.
Conclusions:
- Incorporating nSrCO3 into PCL scaffolds is a viable strategy for bone tissue engineering.
- These nanocomposite scaffolds demonstrate enhanced osteogenesis and cell proliferation, serving as a promising alternative to growth factors for imparting bioactivity.
