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Magnetic and Plasmonic Contrast Agents in Optical Coherence Tomography
Amy L Oldenburg1, Richard L Blackmon2, Justin M Sierchio2
1Department of Physics and Astronomy, the Department of Biomedical Engineering, and the Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3255 USA.
IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-Optics Society
|July 19, 2016
Summary
Magnetic and plasmonic nanoparticles enhance optical coherence tomography (OCT) imaging for biomedical applications. This review covers nanoparticle contrast mechanisms and system requirements for advanced OCT contrast agents.
Area of Science:
- Biomedical Optics
- Nanotechnology
- Medical Imaging
Background:
- Optical coherence tomography (OCT) is a versatile biomedical imaging technique.
- Traditional contrast agents for incoherent imaging are ineffective in OCT.
- Biocompatible nanoparticles offer a solution for OCT contrast enhancement.
Purpose of the Study:
- To review the development of magnetic and plasmonic nanoparticles as OCT contrast agents over the past decade.
- To provide an overview of the physical contrast mechanisms involved.
- To discuss the necessary OCT system hardware add-ons.
Main Methods:
- Review of scientific literature on nanoparticle-based OCT contrast agents.
- Analysis of physical contrast mechanisms (magnetic and plasmonic).
- Categorization of OCT system hardware modifications.
Main Results:
- Iron oxide and noble metal nanoparticles serve as effective OCT contrast agents.
- Magnetic and plasmonic nanoparticles utilize distinct physical principles for contrast generation.
- Specific OCT system hardware configurations are required for each nanoparticle type.
Conclusions:
- Nanoparticle contrast agents significantly expand the capabilities of OCT in biological and pre-clinical studies.
- The choice of nanoparticle system and OCT hardware is application-dependent.
- Further research can optimize nanoparticle-OCT systems for diverse biomedical applications.
Keywords:
Contrast agentsmagnetomotiveoptical coherence tomographyplasmonic nanoparticlessuperparamagnetic iron oxidesMore Related Videos
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