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Related Experiment Video

Updated: Mar 17, 2026

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays

Published on: October 23, 2019

High quality, small molecule-activity datasets for kinase research.

Rajan Sharma¹, Stephan C Schürer², Steven M Muskal¹

¹Eidogen-Sertanty, Inc., Oceanside, CA, 92056, USA.

|November 17, 2016

Summary

This study releases a valuable dataset of 258,000 kinase structure-activity data points and 76,000 chemical structures. This kinase inhibitor data supports research and development for new disease treatments.

Keywords:

Kinase, SAR, Bioactivity Database, Dataset, Drug Discovery, Bioactive Molecules, Kinase Knowledgebase, KKB

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Last Updated: Mar 17, 2026

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays

Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays

Published on: October 23, 2019

Identification of Kinase-substrate Pairs Using High Throughput Screening

Identification of Kinase-substrate Pairs Using High Throughput Screening

Published on: August 29, 2015

Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein

Characterization at the Molecular Level using Robust Biochemical Approaches of a New Kinase Protein

Published on: June 30, 2019

Area of Science:

Biochemistry
Pharmacology
Medicinal Chemistry

Background:

Kinases are crucial regulators of cellular processes, and their dysregulation is implicated in various diseases.
Kinase inhibitors are a significant therapeutic area, generating extensive structure-activity relationship (SAR) data.
Existing bioactivity databases (KKB, WOMBAT, GOSTAR, ChEMBL) compile quantitative compound activity data.

Purpose of the Study:

To foster global methods development and validation in kinase inhibitor research.
To provide a freely accessible, curated dataset for the scientific community.

Main Methods:

Extraction of 258,000 structure-activity data points from the Kinase Knowledgebase (KKB).
Identification and inclusion of 76,000 unique chemical structures associated with these data points.
Focus on data across eight specific kinase targets.

Main Results:

A substantial dataset of kinase SAR data has been compiled and made available.
The dataset includes over 1.8 million data points from the KKB, with 258K extracted for this release.
76K unique chemical structures are linked to the activity data.

Conclusions:

The released dataset offers a valuable resource for researchers studying kinase inhibitors.
Availability of this curated data facilitates the development and validation of new analytical and therapeutic approaches.
This initiative supports the broader scientific community in advancing kinase-targeted drug discovery.