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Clopidogrel-Induced Severe Hepatitis: A Case Report and Literature Review

Hesam Keshmiri1, Anuj Behal1, Shawn Shroff1

  • 1Department of Medicine, Advocate Christ Medical Center, University of Illinois, Oak Lawn, IL 60453, USA.

Case Reports in Hepatology
|July 19, 2016
PubMed

Insights

Severe liver injury from clopidogrel, an antiplatelet medication, is rare but serious. Early detection and stopping the drug are crucial to avoid potentially fatal outcomes.

Area of Science:

  • Hepatology
  • Pharmacology
  • Internal Medicine

Background:

  • Clopidogrel is a widely used antiplatelet medication.
  • Hepatotoxicity is a rare but significant adverse effect associated with clopidogrel therapy.

Purpose of the Study:

  • To report a case of severe clopidogrel-induced hepatitis.
  • To emphasize the importance of liver biopsy in diagnosing drug-induced liver injury.
  • To highlight the necessity of prompt drug withdrawal for patient recovery.

Main Methods:

  • Case report presentation.
  • Detailed clinical history and examination.
  • Liver biopsy for histological assessment.
  • Review of relevant literature.

Main Results:

  • The patient presented with severe hepatitis attributed to clopidogrel.
  • Liver biopsy confirmed drug-induced liver injury.
  • Withdrawal of clopidogrel led to clinical improvement.

Conclusions:

  • Clopidogrel can cause severe hepatotoxicity.
  • Prompt diagnosis and discontinuation of clopidogrel are critical for managing clopidogrel-induced liver injury.
  • Liver biopsy aids in confirming the diagnosis and guiding treatment.

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