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The Value of the P Value.
Dinesh Vyas1, Archana Balakrishnan1, Arpita Vyas1
1College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.
American Journal of Robotic Surgery
|July 19, 2016
Summary
Scientific irreproducibility is a major concern, often linked to the misuse of p-values in null hypothesis testing. This research explores causes, impacts on drug development, and solutions for greater research transparency.
Area of Science:
- Scientific research methodology
- Biostatistics
- Drug development
Background:
- Irreproducibility in scientific research is a widely discussed issue.
- The overuse of p-values for determining statistical significance is a frequently cited cause.
- Concerns exist regarding the reliance on null hypothesis testing in scientific analysis.
Purpose of the Study:
- To survey current issues surrounding research irreproducibility.
- To identify potential causes contributing to the irreproducibility crisis.
- To examine the impact of irreproducibility on drug development and explore transparency efforts.
Main Methods:
- Literature review of current issues in scientific irreproducibility.
- Analysis of the role of p-values and null hypothesis testing.
- Examination of impacts on pharmaceutical research and development.
- Review of strategies to enhance research transparency.
Main Results:
- Overreliance on p-values and null hypothesis testing are significant contributors to irreproducibility.
- Research irreproducibility poses risks to the efficiency and reliability of drug development.
- Various initiatives are underway to promote transparency in scientific findings.
Conclusions:
- Addressing the misuse of statistical significance is crucial for improving research reproducibility.
- Enhanced transparency in research is essential for scientific integrity and progress, particularly in drug development.
- Continued efforts are needed to reform statistical practices and foster a more reproducible scientific landscape.
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