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[Eccrine angiomatous hamartoma: a clinicalopathologic analysis of 4 cases]
Insights
Eccrine angiomatous hamartoma (EAH) is a rare, benign skin tumor. Diagnosis relies on combining clinical, histological, and immunohistochemical findings for accurate identification.
Area of Science:
- Dermatopathology
- Histopathology
- Oncology
Background:
- Eccrine angiomatous hamartoma (EAH) is a rare benign cutaneous hamartoma.
- Understanding its clinical and histopathologic features is crucial for diagnosis.
Purpose of the Study:
- To investigate the clinical and histopathologic features of EAH.
- To clarify the diagnostic and differential diagnostic criteria for EAH.
Main Methods:
- Retrospective analysis of four EAH cases.
- Utilized light microscopy and immunohistochemical staining.
- Reviewed existing literature on EAH.
Main Results:
- EAH presents as solitary papules, plaques, or nodules, often enlarging with patient growth.
- Histopathology reveals eccrine elements associated with angiomatous channels.
- Immunohistochemistry confirmed vascular and eccrine markers, aiding differential diagnosis.
Conclusions:
- EAH is a rare, benign hamartoma of eccrine origin.
- Combined clinical, histological, and immunohistochemical analysis is essential for accurate diagnosis and differentiation from other skin lesions.
Objective:
To investigate the clinical and histopathologic features, diagnosis and differential diagnosis of eccrine angiomatous hamartoma(EAH).
Methods:
Four cases of eccrine angiomatous hamartoma were studied by light microscopy and immunohistochemical staining along with review of the literature.
Results:
There were 3 male and 1 female patients at diagnosis in age of 4 months, 3.5 years, 5.5 years and 14.0 years, respectively. Tumor sites included the left little finger (1 case), right index finger (1 case), lower back (1 case) and knee (1 case). Clinically, most cases presented as a solitary, flesh or reddish papule, plaque or nodule with size of 0.4-6.0 cm in diameter. The skin lesions in 3 cases enlarged commensurate with the growth of the patients, and local hyperhidrosis in one case. Histologically, EAH was characterized by proliferation of well-differentiated eccrine secretory and ductal elements closely associated with thin-walled angiomatous channels in the middle or deep dermis and subcutaneous tissue. By immunohistochemistry, the vascular components were positive for CD31, CD34 and factor Ⅷ related antigen while the eccrine glands were positive for S-100 protein, CEA, EMA, CAM5.2 and GCDFP15. Local surgical resection was performed in 4 cases and follow-up data (0.5 to 4.5 years) showed no recurrence.
Conclusion:
EAH is a rare, benign cutaneous hamartoma. Combination of clinical manifestations, histological changes and immunohistochemical findings is useful for the diagnosis and differential diagnosis.
