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Does cholecystokinin induce physiological satiety and sleep?
Z de Saint Hilaire-Kafi1, H Depoortere, S Nicolaïdis
1Neurobiologie des Régulations, Collège de France, Paris.
Brain Research
|May 29, 1989
Summary
High doses of cholecystokinin octapeptide (CCK-8) increased slow wave sleep in fasted rats, suggesting CCK-8 may influence sleep. Lower doses showed no significant sleep alterations.
Area of Science:
- Neuroscience
- Gastroenterology
- Sleep Medicine
Background:
- Cholecystokinin octapeptide (CCK-8) is known for its role in satiety and gastrointestinal function.
- The influence of CCK-8 on sleep architecture and electroencephalogram (EEG) patterns requires further investigation.
Purpose of the Study:
- To investigate the effects of two different anorexigenic doses of CCK-8 on sleep parameters in fasted rats.
- To analyze EEG spectral changes induced by CCK-8 administration.
Main Methods:
- Intraperitoneal administration of CCK-8 at doses of 8 and 16 micrograms/kg in fasted rats.
- Monitoring of sleep parameters and EEG recordings.
- EEG spectral analysis to assess frequency and power energy.
Main Results:
- The high dose (16 micrograms/kg) of CCK-8 significantly increased slow wave sleep within the first 30 minutes.
- The low dose (8 micrograms/kg) of CCK-8 did not significantly alter sleep parameters.
- Both doses induced EEG spikes and unusual slow waves, with CCK-8 slowing EEG frequency without altering total power energy.
Conclusions:
- CCK-8, particularly at higher doses, can modulate sleep patterns, specifically increasing slow wave sleep.
- The observed EEG changes suggest a direct effect of CCK-8 on brain activity related to sleep.
- The findings question whether CCK-8 fully replicates all physiological effects of satiety, including normal sleep.