Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inner perineurial cell vulnerability in ischemia.

T J Benstead1, P J Dyck, V Sangalang

  • 1Department of Medicine, Dalhousie University, Victoria General Hospital, Halifax, N.S., Canada.

Brain Research
|June 5, 1989
PubMed
Summary

Peripheral nerve injury causes early degeneration in the inner perineurial sheath, impacting endoneurial fluid balance and nerve fiber integrity. This study reveals key structural changes following ischemic injury.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early data on long-term efficacy and safety of inotersen in patients with hereditary transthyretin amyloidosis: a 2-year update from the open-label extension of the NEURO-TTR trial.

European journal of neurology·2020
Same author

Does prediabetes cause small fiber sensory polyneuropathy? Does it matter?

Journal of the neurological sciences·2015
Same author

Retrospective study of a TTR FAP cohort to modify NIS+7 for therapeutic trials.

Journal of the neurological sciences·2014
Same author

Autonomic dysfunction in chronic inflammatory demyelinating polyradiculoneuropathy.

Neurology·2012
Same author

The diflunisal trial: update on study drug tolerance and disease progression.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis·2011
Same author

TRPV4 mutations and cytotoxic hypercalcemia in axonal Charcot-Marie-Tooth neuropathies.

Neurology·2011

Area of Science:

  • Neuroscience
  • Cell Biology
  • Peripheral Nerve Anatomy

Background:

  • The perineurium is crucial for peripheral nerve structure, fluid homeostasis, and strength.
  • Limited knowledge exists regarding perineurial alterations following injury.

Purpose of the Study:

  • To investigate the structural changes in the perineurium after ischemic injury.
  • To identify early reactive cellular changes in perineurial cells.

Main Methods:

  • Induction of ischemic injury by ligating lower limb arteries in Sprague-Dawley rats.
  • Microscopic examination of perineurial tissue at 36 hours and 7 days post-injury.

Main Results:

  • Lipid droplet accumulation observed in perineurial, endothelial, and Schwann cells as an early response to ischemia.

Related Experiment Videos

  • Widening and degeneration of the inner perineurial sheath in areas with myelinated fiber injury.
  • Inner perineurial cells exhibited swelling, organelle damage, and membrane dissolution, while outer layers remained intact.

    • Conclusions:

    • Inner perineurial cell degeneration is a significant early indicator of ischemic peripheral nerve injury.
    • These degenerative changes may disrupt endoneurial homeostasis and affect nerve fiber function and structure.