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Infective Endocarditis Caused by Panton-Valentine Leukocidin-producing Methicillin-susceptible Staphylococcus aureus

Hiroshi Nakajima1, Kaoru Dohi, Masaki Tanabe

  • 1Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Japan.

Internal Medicine (Tokyo, Japan)
|July 20, 2016
PubMed

Insights

This study reports the first case of infective endocarditis caused by Panton-Valentine leukocidin-producing methicillin-susceptible Staphylococcus aureus (PVL-MSSA). This rare pathogen led to severe heart failure despite initial antibiotic treatment.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Microbiology

Background:

  • Infective endocarditis (IE) is a serious infection of the heart valves.
  • Methicillin-susceptible Staphylococcus aureus (MSSA) can cause IE, but PVL-producing strains are rarely implicated.

Observation:

  • A 76-year-old man presented with fever and developed heart failure due to aortic and mitral valve insufficiency.
  • Despite negative blood cultures, molecular analysis detected Panton-Valentine leukocidin (PVL)-producing MSSA in whole blood.

Findings:

  • The patient was diagnosed with IE caused by PVL-producing MSSA.
  • This represents the first reported case of IE attributed to this specific strain of Staphylococcus aureus.

Implications:

  • Highlights the importance of molecular diagnostics in identifying causative pathogens when cultures are negative.
  • Suggests PVL-producing MSSA should be considered in severe IE cases, even without typical risk factors.

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