Association of elevated triglycerides and acute myocardial infarction in young Hispanics
Gilbert Essilfie1, David M Shavelle1, Han Tun1
1Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033.
Insights
Young Hispanic individuals experiencing acute myocardial infarction (AMI) show higher triglyceride levels compared to other groups. These elevated levels may stem from lifestyle shifts associated with immigration to the United States.
Area of Science:
- Cardiology
- Ethnic Health Disparities
- Metabolic Syndrome
Background:
- Acute myocardial infarction (AMI) in younger patients (<45 years) is linked to smoking, obesity, and hyperlipidemia.
- Hispanics are the largest growing ethnic minority in the U.S., but AMI characteristics in young Hispanics remain understudied.
Purpose of the Study:
- To describe the unique features of AMI in young Hispanic patients.
- To compare young Hispanic AMI patients with young non-Hispanic and older Hispanic patients.
Main Methods:
- Retrospective study of patients undergoing percutaneous coronary intervention for AMI.
- Comparison of young Hispanics (age <45) with older patients (age ≥45) and young non-Hispanics.
- Multivariable logistic regression to identify factors associated with in-hospital mortality.
Main Results:
- Young Hispanics exhibited significantly higher triglyceride levels than young non-Hispanics and older patients (p<0.0004).
- Body mass index was independently associated with triglyceride levels (p<0.0001).
- Hispanic ethnicity and age <45 were not independently associated with in-hospital mortality.
Conclusions:
- Young Hispanic patients with AMI present with elevated triglyceride levels compared to other demographic groups.
- Lifestyle changes in young immigrant populations transitioning to the U.S. may contribute to these elevated triglyceride levels.
Background:
Previous studies have demonstrated that acute myocardial infarction (AMI) in young patients (age <45years) is associated with a high prevalence of smoking, obesity, hyperlipidemia and single vessel coronary artery disease (CAD). Hispanics represent the largest growing ethnic minority in the United States, yet features of AMI in young Hispanics have not been described.
Methods:
Patients undergoing percutaneous coronary intervention for AMI at Los Angeles County + University of Southern California Medical Center and Keck Medical Center were studied. We compared young Hispanics (age<45, n=47) with older patients (Hispanics and non-Hispanics age ≥45, n=888) to identify unique features of AMI in young Hispanics. We also compared young Hispanics with young non-Hispanics (n=33) and older Hispanics (n=447) in regards to traditional CAD risk factors, laboratory values and in-hospital outcomes. Multivariable logistic regression was performed to identify variables independently associated with in-hospital mortality.
Results:
Young Hispanics had higher triglyceride levels than young non-Hispanics and older patients (234.5±221.0mg/dL vs. 145.3±67.4mg/dL vs. 156±118.2mg/dL, p<0.0004); and higher triglyceride than older Hispanics (234.5±221.0 vs. 147.0±98.9mg/dL, p<0.02). Body mass index was independently associated with the logarithm (base10) of triglyceride levels (p<0.0001). Hispanic ethnicity and age<45years, however, were not independently associated with in-hospital mortality.
Conclusions:
Young Hispanics with AMI have higher triglyceride levels than young non-Hispanics and older Hispanics. The elevated triglyceride levels may be related to lifestyle changes experienced by a young immigrant population transitioning to life in the United States.
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