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Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
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Hemorrhagic cerebrovascular disease.
Javier M Romero1, Jonathan Rosand2
1Department of Neuroradiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Handbook of Clinical Neurology
|July 20, 2016
Summary
Intracerebral hemorrhage (ICH) is a severe stroke type with high mortality. Advanced neuroimaging like CT, MRI, and DSA are crucial for diagnosis and guiding treatment decisions in patients with spontaneous ICH.
Area of Science:
- Neurology
- Radiology
- Neurosurgery
Background:
- Intracerebral hemorrhage (ICH) constitutes 10-15% of all strokes, presenting a significant mortality risk.
- Associated intraventricular hemorrhage increases 1-month mortality to nearly 50% and 6-month dependency to 80%.
Purpose of the Study:
- To review current neuroimaging approaches for intracerebral hemorrhage (ICH).
- To present a differential diagnosis of etiologies and imaging findings for primary and secondary intraparenchymal hemorrhage.
Main Methods:
- Review of current neuroimaging modalities including computed tomography (CT), magnetic resonance imaging (MRI), and digital subtraction angiography (DSA).
- Analysis of imaging manifestations for differential diagnosis of ICH etiologies.
Main Results:
- Neuroimaging is critical for identifying ICH etiology and informing therapeutic decisions.
- Active bleeding and potential hematoma expansion in the early hours post-ICH onset are key research areas.
Conclusions:
- Effective use of neuroimaging (CT, MRI, DSA) is vital for managing patients with spontaneous intracerebral hemorrhage (ICH).
- Ongoing research focuses on identifying patients at risk for hematoma expansion for targeted therapeutic trials.
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