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Adrenal cortical carcinoma.

S Venkatesh1, R C Hickey, R V Sellin

  • 1Department of Medical Specialties, University of Texas M.D. Anderson Cancer Center, Houston 77030.

Cancer
|August 1, 1989
PubMed
Summary
This summary is machine-generated.

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Complete surgical excision offers the best survival for adrenal cortical carcinoma. Adjuvant 1,1-dichloro-2-(O-chlorophenyl)-2-(P-chlorophenyl)ethane (OPDDD) shows promise, warranting further study for this rare cancer.

Area of Science:

  • Endocrinology
  • Oncology
  • Surgical Pathology

Background:

  • Adrenal cortical carcinoma is a rare and aggressive endocrine malignancy.
  • Understanding prognostic factors and treatment efficacy is crucial for patient outcomes.

Purpose of the Study:

  • To analyze survival rates and treatment effectiveness in patients with adrenal cortical carcinoma.
  • To evaluate the role of surgery, radiotherapy, chemotherapy, and OPDDD in managing this disease.

Main Methods:

  • Retrospective review of 110 patients with histologically confirmed adrenal cortical carcinoma.
  • Analysis of presenting symptoms, treatment modalities (surgery, radiotherapy, chemotherapy, OPDDD), and survival data.
  • Assessment of disease-free survival and overall survival rates based on treatment interventions.

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Main Results:

  • 50.9% of patients presented with abdominal symptoms; 30.0% had a palpable abdominal mass.
  • Disease-free survival of at least 2 years was achieved by 56% of patients undergoing surgery for localized/regional disease.
  • 1,1-dichloro-2-(O-chlorophenyl)-2-(P-chlorophenyl)ethane (OPDDD) showed a 29.2% response rate; adjuvant OPDDD demonstrated promising survival in 6 of 7 patients.

Conclusions:

  • Early diagnosis and complete surgical resection are paramount for achieving long-term survival in adrenal cortical carcinoma.
  • Adjuvant therapy with OPDDD warrants further investigation due to observed survival benefits.
  • Distant metastases commonly affect the lungs, liver, peritoneum, lymph nodes, and bones.