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Cyclodextrins 3-Functionalized with 8-Hydroxyquinolines: Copper-Binding Ability and Inhibition of Synuclein

Valentina Oliveri1,2, Carmelo Sgarlata1, Graziella Vecchio3

  • 1Dipartimento di Scienze Chimiche, Università degli Studi di Catania, viale A. Doria 6, 95125, Catania, Italy.

Chemistry, an Asian Journal
|July 20, 2016
PubMed

Keywords:
chelatescopperglycoconjugatesinhibitorsmetal complexes

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In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
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