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Related Concept Videos

Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

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Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
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Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

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γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
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Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

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Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
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Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

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Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
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Antiepileptic Drugs: Calcium Channel Blockers01:17

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Calcium channel blockers, a class of antiepileptic drugs, regulate the flow of calcium ions within neurons.
Calcium channel blockers exert their antiepileptic effects by targeting T-type calcium channels, which are integral to transmitting nerve signals in the central nervous system. These channels allow the passage of calcium ions, which are vital for neuronal communication. By inhibiting T-type calcium channels, calcium channel blockers effectively reduce the release of neurotransmitters and...
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Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

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Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
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Related Experiment Video

Updated: Mar 17, 2026

Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement
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Clobazam and Its Use in Epilepsy.

Marius Pernea1, Alastair G Sutcliffe1

  • 1Department of Pediatrics, Institute of Child Health, University College London , UK.

Pediatric Reports
|July 20, 2016
PubMed
Summary

Clobazam (CLB), an anti-epileptic drug, offers effective seizure control with fewer sedative effects than traditional benzodiazepines. This review examines its efficacy as adjunctive therapy across various epilepsy types.

Area of Science:

  • Pharmacology
  • Neurology
  • Clinical Medicine

Background:

  • Clobazam (CLB) is an established anti-epileptic drug with a unique chemical structure.
  • It exhibits comparable efficacy to classic benzodiazepines but with reduced sedative adverse effects.
  • CLB is widely approved and utilized globally as an adjunctive epilepsy treatment.

Purpose of the Study:

  • To review existing studies on the effectiveness of Clobazam (CLB) as adjunctive therapy for epilepsy.
  • To determine if CLB is more beneficial for specific epilepsy types or seizure prevention.
  • To evaluate the advantages of CLB oral suspension and the implications of branded vs. generic prescribing.

Main Methods:

  • This study is a general overview, not a systematic review.
Keywords:
Clobazamadjunctive therapygeneric prescribingoral suspension

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  • It synthesizes findings from recent studies on Clobazam (CLB) effectiveness.
  • Patient groups benefiting from the oral suspension formulation are considered.

    • Main Results:

    • Clobazam (CLB) demonstrates significant efficacy as an adjunctive treatment for epilepsy.
    • Its tolerability and reduced sedation profile are highlighted.
    • The oral suspension offers formulation benefits for specific patient populations.

    Conclusions:

    • Clobazam (CLB) is a well-tolerated and effective adjunctive therapy for epilepsy.
    • Its utility may vary across different epilepsy types, warranting further investigation.
    • Prescribing Clobazam (CLB) by brand is discussed regarding potential benefits and risks.