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Ustekinumab in Crohn's disease: evidence to date and place in therapy

Tal Engel1, Uri Kopylov2

  • 1Department of Gastroenterology, Sheba Medical Center Tel Hashomer, Sackler School of Medicine, Tel-Aviv University, Tel Hashomer, Israel.

Therapeutic Advances in Chronic Disease
|July 20, 2016
PubMed

Crohn's disease (CD) is an inflammatory bowel disease (IBD) with uncertain etiology. Biologic agents have revolutionized the treatment of CD but nonresponders remain a challenge. Ustekinumab is an interleukin 12/23p40 inhibitor that was recently found effective in treating CD. We reviewed the current literature regarding the efficacy of ustekinumab in treating CD and concluded that ustekinumab is a novel, promising and relatively safe agent for the treatment of moderate to severe CD. Additional data from randomized controlled studies and real-life cohorts are pending.

Keywords:
Crohn’s diseaseinterleukin 12/23p40 inhibitorustekinumab

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