Related Experiment Video
Updated: Mar 17, 2026

Chronic Ovine Model of Right Ventricular Failure and Functional Tricuspid Regurgitation
Published on: March 17, 2023
Triple Valvulopathy and Jaccoud's Arthropathy: A Case Report and Literature Review
Ali Naderi Mahabadi1, Bassam Alhaddad2, Stanley Ballou2
1Department of Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, OH 44109, USA.
Insights
Systemic lupus erythematosus (SLE) can affect the heart valves, leading to rare cases of severe valvulitis. This case highlights a fatal outcome despite multiple valve replacements due to aggressive SLE.
Area of Science:
- Cardiology
- Rheumatology
- Immunology
Background:
- Cardiac involvement is a known complication of systemic lupus erythematosus (SLE).
- Lupus can affect the heart's layers, coronary arteries, and valves.
Purpose of the Study:
- To report an extremely rare case of lupus valvulitis and dysfunction.
- To discuss the implications of aggressive disease presentation and treatment challenges.
Main Methods:
- Case report presentation.
- Review of clinical course and management.
Main Results:
- The patient presented with severe valvulitis and valvular dysfunction due to SLE.
- Three mechanical prosthetic valve replacements were necessitated by the disease.
- Disease recurrence occurred, leading to a fatal outcome.
Conclusions:
- Lupus valvulitis can have an aggressive natural history.
- Late diagnosis or unsuccessful treatment of SLE may contribute to poor outcomes.
- This case underscores the critical need for timely SLE management to prevent severe cardiac complications.
Abstract:
Cardiac involvement is fairly common in patients with systemic lupus erythematosus (SLE). It may involve all layers of the heart and coronary arteries as well as the heart valves. We report an extremely rare presentation of valvulitis and valvular dysfunction associated with systemic lupus erythematosus. This is the first case of lupus valvulitis which required three mechanical prosthetic valve replacements with disease recurrence leading to a fatal outcome. This is, in our point of view, the consequence of aggressive natural history of the disease and perhaps late diagnosis and treatment of underlying SLE which was unsuccessful.
More Related Videos
07:38Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
Published on: January 20, 2023
08:34Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
Published on: November 18, 2018
Related Concept Videos
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Mitral Valve Prolapse II: Assessment and Management
Mitral Regurgitation I: Introduction
Rheumatic Heart Disease I: Introduction
Aortic Regurgitation I: Introduction
Mitral Regurgitation III: Medical Management