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Dyslipidemia in Psoriasis: A Case Controlled Study.
Y C Nakhwa1, R Rashmi2, K H Basavaraj2
1Department of Dermatology, Mahatma Gandhi Medical College & Research Institute, Pondicherry 605007, India.
International Scholarly Research Notices
|July 20, 2016
Summary
This study found significant lipid abnormalities, including elevated cholesterol and triglycerides, in Indian psoriasis patients. Lower high-density lipoprotein (HDL) levels correlated with increased psoriasis severity and duration.
Area of Science:
- Dermatology
- Cardiovascular Health
- Metabolic Disorders
Background:
- Psoriasis is linked to metabolic syndrome, including dyslipidemia.
- Limited Indian research exists on dyslipidemia in psoriasis patients.
Purpose of the Study:
- To assess serum lipid profiles in Indian psoriasis patients.
- To investigate the association between lipid levels and psoriasis severity/duration.
Main Methods:
- 100 psoriasis patients and 73 controls were recruited.
- Psoriasis Area Severity Index (PASI) graded disease severity.
- Serum lipids (cholesterol, triglycerides, HDL, VLDL, LDL) were analyzed.
Main Results:
- Psoriasis patients showed elevated serum cholesterol, triglycerides, HDL, and VLDL compared to controls.
- Low-density lipoprotein (LDL) levels were similar between groups.
- HDL levels decreased with increasing disease severity and duration.
- Lipid aberrations were significant in hypertensive psoriasis patients.
Conclusions:
- A strong association exists between dyslipidemia and psoriasis in the Indian population.
- Dyslipidemia is a consistent comorbidity across diverse populations with psoriasis.
- Further research is needed to explore potential genetic factors in psoriasis-related lipid derangements.
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