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High-Throughput Optical Sensing Immunoassays on Smartphone.

Li-Ju Wang¹, Rongrong Sun¹, Tina Vasile²

¹School of Mechanical and Materials Engineering, Washington State University , Pullman, Washington 99164, United States.

Analytical Chemistry

|July 20, 2016

Summary

A novel smartphone-based optical sensing platform enables high-throughput screening of 64 samples for immunoassays. This low-cost, portable device accurately detects biomarkers and plant viruses, decentralizing lab testing for rapid disease detection.

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Area of Science:

Biomedical Engineering
Optical Sensing
Point-of-Care Diagnostics

Background:

High-throughput screening immunoassays are crucial for disease detection.
Current laboratory methods can be time-consuming and require specialized equipment.
Decentralized diagnostic tools are needed for rapid, on-site analysis.

Purpose of the Study:

To develop a cost-effective, high-throughput optical sensing platform integrated with a smartphone.
To demonstrate the platform's capability for detecting biomarkers and plant viruses.
To validate the accuracy and reliability of smartphone-based immunoassays.

Main Methods:

Utilized a designed microprism array for simultaneous screening of 64 samples.
Developed a smartphone-based optical sensing system for immunoassay detection.
Performed immunoassays for human interleukin 6 (IL-6) protein and six types of plant viruses.

Main Results:

Achieved 99.1% accuracy in quantifying IL-6 protein concentrations.
Demonstrated high accuracy (96.2-99.9%) in detecting six types of plant viruses across 1030 samples.
The platform costs approximately $50 USD, reads 64 samples in 2 seconds, and is portable.

Conclusions:

The smartphone-based optical sensing platform offers a viable solution for in situ, high-throughput immunoassays.
This technology can decentralize laboratory testing for viruses, pathogens, biomarkers, and toxins.
Enables timely disease spread containment through rapid, mobile point-of-care diagnostics.